ncRNA name | XIST |
ncRNA Category | lncRNA |
ID | 7503 |
Ensembl | ENSG00000229807 |
Synonyms | DXS1089, DXS399E, LINC00001, NCRNA00001, swd66 |
Disease name | uveal melanoma (UM) |
Species | Homo sapiens |
Tissues/Cell_line | UM cell lines MUM2B, 92.1, OCM1, OCM1A, OM431 and SP6.5; human embryonic kidney cell line HEK293T; RPE cell line ARPE19; female uveal tissue cell line FPC1 |
Methods | RT-PCR, qRT-PCR, transwell assay, xenograft, microarray, RNA FISH, ChOP, CHIP |
Expression pattern | up-regulated |
Functional description | XIST lncRNA serves as a potential target of CANT1, and JPX or FTX lncRNA subsequently serves as a contextual hinge to activate a novel CANT1-JPX/FTX-XIST long non-coding (lncing) pathway in UM. |
PubMed ID | 28330694 |
Year | 2017 |
Title | CANT1 lncRNA Triggers Efficient Therapeutic Efficacy by Correcting Aberrant lncing Cascade in Malignant Uveal Melanoma. |
Drug-related ncRNA | NO |
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